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Robert Gardiner et al, from the University of Queenland, Royal Adelaide Hospital Cancer Center, and University of Adelaide Hanson Institute wrote in journal of the European Association of Urology in 2009 It has been documented recently that intrtumoural androgen levels in castrate resistant prostate cancer are sufficient to stimulate tumor growth, indicating that local synthesis of androgens is another mechanism for maintaining androgen receptor signalling in the castrate environment buy cialis with paypal