Pregunta
furosemide lasix Mechanistically, expression of the hypertension causing CUL3О”9 mutation impairs vascular function as a result of a compromised endogenous CUL3 activity resulting in decreased turnover of RhoA and elevated RhoA and ROCK activity, b impaired response to endothelial derived NO dependent relaxation, c enhanced agonist induced vasocontraction, and d increased arterial stiffness and fibrosis that reduce arterial compliance, all of which cause hypertension and increased susceptibility to an agonist induced hypertension
