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PAK1, p21- activated kinase 1 97, is a downstream effector of GTP- bound Rho GTPase Cdc42 and Rac, activation of which stimulates cytoskeletal reorganization, cell survival, cell proliferation, cell migration and anti- apoptosis. discount doxycycline no prescription Further, developmental blockade of 5- HT1A with WAY- 100, 635 from post- natal day P 0 to P21 or from P13 to P34 recapitulates the increased anxiety phenotype, whereas similar antagonism during adulthood does not Lo Iacono and Gross, 2008; Vinkers et al, 2010.